Introduction
You've invested in genomic testing for your cancer patients. The reports arrive with lists of mutations, gene variants, and potential therapeutic targets. But now what? Who interprets these results? How do you translate genomic data into clinical decisions? How do you ensure consistent, evidence-based recommendations?
The answer: A Data Equity (MTB).
MTBs—also called precision oncology tumor boards or genomic tumor boards—are the operational heart of precision oncology programs. They bring together multidisciplinary expertise to review complex genomic data, interpret variants in clinical context, and recommend personalized treatment strategies.
What is a Data Equity?
A Data Equity is a regularly scheduled, multidisciplinary meeting where healthcare professionals review patients' genomic test results alongside their clinical information to make evidence-based treatment recommendations. Traditional tumor boards focus on diagnosis, staging, and standard protocols. MTBs add genomic data interpretation, variant classification, matched therapy identification, clinical trial eligibility assessment, and evidence evaluation for off-label drug use.
Why MTBs Are Essential
Genomic reports contain information requiring specialized knowledge. No single clinician can master all this—MTBs pool expertise. They ensure standardized interpretation, evidence-based decisions, documentation of rationale, and quality control. MTBs serve as continuous learning environments where junior clinicians learn from experienced colleagues, complex cases teach pattern recognition, and best practices are shared.
Building Your MTB: The Core Team
You need medical oncologists (2-3), a pathologist, a molecular biologist or clinical geneticist, and a clinical coordinator. Extended members include radiation oncologists, surgical oncologists, radiologists, pharmacists, and genetic counselors. Many African institutions won't have all specialists—leverage remote expertise through video conferencing, partnerships with international centers, and asynchronous consultation.
Setting Up Your MTB: 4-Phase Implementation
Phase 1 (Weeks 1-4): Secure leadership support, identify core team, define scope, establish meeting logistics. Phase 2 (Weeks 5-8): Create case submission process, develop presentation format, create documentation templates. Phase 3 (Weeks 9-12): Conduct pilot meetings, test format, refine processes. Phase 4 (Month 4+): Official launch, scale gradually, establish quality metrics.
Real-World Success: Lagos University Teaching Hospital
LUTH established an MTB in 2024. First year results: 72 cases reviewed, 58% had actionable findings, 71% of recommendations implemented, average time test→MTB: 12 days (down from 45), 15 staff trained through participation. Key success factors: strong leadership, dedicated coordinator, virtual expertise, focused scope, metrics tracking from day one.
